Welcome to Wang Laboratory!
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The Demand:
The rapid advancement of multi-omics sequencing technologies and the completion of large-scale cancer genome projects have produced an overwhelming amount of data, heralding new discoveries in cancer research and precision oncology. With the introduction of the UG100 sequencer, affordable $100 whole genome sequencing is on the horizon. These developments necessitate innovative and integrative computational and machine learning technologies to tackle the major challenges in cancer pathobiology, immunobiology, and therapeutics, and to fully realize the potential of precision oncology driven by big data.
Our Research:
Wang laboratory is a computational genomics and translational cancer biology lab at UPMC Hillman Cancer, University of Pittsburgh. The mission of our lab is to apply a multiple disciplinary approach inclusive of bioinformatics, machine learning, genetics, molecular and cell biology, and translational studies to explore the dark-side of cancer genetics, discover viable cancer targets, and achieve big-data based precision therapeutics on the basis of multi-omics deep sequencing technologies.
Our Goals:
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Develop integrative computational genomics approaches to discover causal genetic alternations, viable therapeutic targets, and precision oncology biomarkers in cancer.
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Experimentally characterize driving genetic aberrations, therapeutic targets, and predictive/diagnostic biomarkers for the development of new cancer precision medicine.
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Develop novel genomic markers and machine-learning models to predict therapeutic responses of cancer targeted therapies and immunotherapies, as well as to facilitate clinically important decisions.