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*   Study shines light on genetic aberrations of aggressive breast cancers

*   A step-by-step guide to Concept Signature (ConSig) Analysis

*   Heterogeneous Expression Profile Analysis: discovering tumor specific genome.

Welcome to Wang Laboratory

The Demand of the Cancer Genome:

The advancements of high-throughput transcriptomic, genomic and deep sequencing technologies have generated a flood of data in the public domain and private warehouse. However, the laboratory discoveries based on the analysis of these data have met with limited success. Innovative computational technologies and integrated experimental approaches that can address the driving biological problems in cancer are of high demand.

Figure1. Decoding the Cancer Genome for the Cure ...

Our Lab Scheme:

Wang laboratory is a cancer genomics and molecular targeting lab at University of Pittsburgh Cancer Institute. The mission of our lab is to apply a multiple disciplinary approach inclusive of bioinformatics, genetics, molecular and cell biology, and translational studies to detect driving genetic aberrations and qualify appropriate cancer targets on the basis of next generation sequencing and genome profiling technologies.

Research Goals:

  • Develop integrative computational genomics approaches to discover causal genetic alternations, viable therapeutic targets, and predictive biomarkers in cancer.
  • Experimentally characterize driving genetic aberrations, therapeutic targets, and predictive biomarkers for the development of new cancer precision medicine.
  • Develop novel bioinformatics tools and models to predict therapeutic responses of cancer targeted therapies and immunotherapies, as well as to facilitate clinically important decisions.

Wang Laboratory @ University of Pittsburgh Cancer Institute.