Welcome to Wang Laboratory!

The Demand of the Cancer Genome:

The advancements of high-throughput transcriptomic, genomic and deep sequencing technologies have generated a flood of data in the public domain and private warehouse. However, the laboratory discoveries based on the analysis of these data have met with limited success. Innovative computational technologies and integrated experimental approaches that can address the driving biological problems in cancer are of high demand.

Our Research:

Wang laboratory is a computational genomics and translational cancer biology lab at UPMC Hillman Cancer, University of Pittsburgh. The mission of our lab is to apply a multiple disciplinary approach inclusive of bioinformatics, genetics, molecular and cell biology, and translational studies to explore the dark-side of cancer genetics, discover viable cancer targets, and achieve precision therapeutics on the basis of next generation sequencing and genome profiling technologies.

Our Research Goals:

  • Develop integrative computational genomics approaches to discover causal genetic alternations, viable therapeutic targets, and predictive biomarkers in cancer.
  • Experimentally characterize driving genetic aberrations, therapeutic targets, and predictive biomarkers for the development of new cancer precision medicine.
  • Develop novel bioinformatics tools and models to predict therapeutic responses of cancer targeted therapies and immunotherapies, as well as to facilitate clinically important decisions.

Our Aspiration:

Let each hour of our work translate into 50 years of aggregated human life.