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Publications


·      Panebianco F, Kelly LM, Liu P, Zhong S, Dacic S, Wang XS, Singhi AD, Dhir R, Chiosea SI, Kuan SF, Bhargava R, Dabbs D, Trivedi S, Gandhi M, Diaz R, Wald AI, Carty SE, Ferris RL, Lee AV, Nikiforova MN, Nikiforov YE.
THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer.
PNAS
2017. 10.1073/pnas.1614265114.

 

·    Yu L, Liang Y, Cao X, Wang X, Gao H, Lin SY, Schiff R, Wang XS#, Li K#.
Identification of MYST3 as a novel epigenetic activator of ERα frequently amplified in breast cancer.
Oncogene 2016 10.1038/onc.2016.433.

 

·       Kim JA, Tan Y, Wang X, Cao X, Veeraraghavan J, Liang Y, Edwards DP, Huang S, Pan X, Li K, Schiff R. and Wang XS#.
Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers.
Nature Communications
. 2016 Oct 3;7:12991.

 

·       Kim JA, Anurag M, Veeraraghavan J, Schiff R, Li K, Wang XS#.
Amplification of TLK2 Induces Genomic Instability via Impairing the G2/M Checkpoint.
Mol Cancer Res. 2016 Aug 3. pii: molcanres.0161.2016.

 

·       Veeraraghavan J, Ma J, Hu Y, Wang XS#.
Recurrent and pathological gene fusions in breast cancer: current advances in genomic discovery and clinical implications.
Breast
Cancer Res Treat. 2016 Jul;158(2):219-32.

 

·       Qin L, Xu Y, Xu YX, Ma G, Liao L, Wu YL, Li Y, Wang X, Wang XS, Jiang J, Wang J, and Xu JM.
NCOA1 Promotes Angiogenesis in Breast Tumors by Simultaneously Enhancing both HIF1α- and AP-1-mediated VEGFa Transcription.
Oncotarget.
2015 6:23890-904.

 

·       Song XZ, Zhang CW, Zhao MK, Chen H, Liu X, Chen JW, Lonard DM, Qin L, Xu JM, Wang XS, Li F, O’Malley BW, Wang J.
Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug.
PLOS ONE. 2015 DOI: 10.1371/journal.pone.0140011.

 

·       Veeraraghavan J*, Tan Y*, Cao XX*, Kim JA, Wang X, Chamness GC, Maiti SN, Cooper LJN, Edwards DP, Contreras A, Hilsenbeck SG, Chang EC, Schiff R, Wang XS#.
Recurrent ESR1-CCDC170 rearrangements in an aggressive subset of estrogen-receptor positive breast cancers. 
Nature Communications. 2014 5:4577. doi: 10.1038/ncomms5577.

 

·       Fan Y*, Ge N*, Wang XS*, Sun W*, Mao R, Bu W, Creighton CJ, Zheng P, Vasudevan S, An L, Yang J, Zhao YJ, Zhang H, Li XN, Rao PH, Leung E, Lu YJ, Gray JW, Schiff R, Hilsenbeck SG, Osborne CK, Yang J, Zhang H.
Amplification and overexpression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells. 
The Journal of Pathology 2014 232:75-86.

 

·       Yang Y, Zhao W, Xu QW, Wang XS, Zhang Y, Zhang J.
IQGAP3 Promotes EGFR-ERK Signaling and the Growth and Metastasis of Lung Cancer Cells. 
PLOS One. 2014 9:e97578.

 

·       Yin B, Zeng Y, Wang XS, Liu G, Zhang M, Song Y.
Expression and clinical significance of cancer-testis genes in clear cell renal cell carcinoma.
Int J Clin Exp Pathol. 2014 7:4112-9.

 

·       Xu QW, Zhang Y, Wang XS#. 
[Author’s View] HEPA and PARSE: Systematic discovery of clinically relevant tumor-specific antigens.
Oncoimmunology. 2013 3:e23249

 

·       Xu QW, Zhao W, Wang Y, Sartor MA, Han DM, Deng JX, Ponnala R, Yang JY, Zhang QY, Liao GQ, Qu YM, Li L, Liu FF, Zhao HM, Yin YH, Chen WF, Zhang Y#Wang XS#.
An integrated genome-wide approach to discover tumor specific antigens as potential immunological and clinical targets in cancer.
Cancer Research. 2012 72:6351-61

 

·       Yin B, Liu G, Wang XS, Zhang H, Song YS, Wu B.
Expression profile of cancer-testis genes in transitional cell carcinoma of the bladder. 
Urologic Oncology. 2012 30:886-92

 

·       Wang XS*, Shankar S*, Dhanasekaran SM*, Ateeq B, Sasaki AT, Jing X, Robinson D, Cao Q, Prensner JR, Yocum AK, Wang R, Fries DF, Han B, Asangani IA, Cao X, Li Y, Omenn GS, Pflueger D, Gopalan A, Reuter VE, Kahoud ER, Cantley LC, Rubin MA, Palanisamy N, Varambally S, Chinnaiyan AM.  
Characterization of KRAS Rearrangements in Metastatic Prostate Cancer.
Cancer Discovery. 2011 1:35-43.

 

·       Lai YQ, Ye JX, Chen J, Zhang LB, Wasi LJ, He ZS, Zhou LQ, Li H, Yan QX, Gui YT, Cai ZM, Wang XS#, Guan ZC#.
UPK3A: A Promising Novel Urinary Marker for the Detection of Bladder Cancer.
Urology. 2010 76:514

 

·       Wang XSPrensner JR, Chen G, Cao Q, Han B, Dhanasekaran SM, Ponnala R, Cao X, Varambally S, Thomas DG, Giordano TJ, Beer DG, Palanisamy N, Sartor MA, Omenn GS, Chinnaiyan AM.
An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancer. 
Nature Biotechnology. 2009 27:1005-1011

 

·       Varambally S, Cao Q, Mani RS, Shankar S, Wang XS, Ateeq B, Laxman B, Cao X, Jing X, Ramnarayanan K, Brenner JC, Yu J, Kim JH, Han B, Tan P, Kumar-Sinha C, Lonigro RJ, Palanisamy N, Maher CA, Chinnaiyan AM.  
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.
Science. 2008 5908:1695-9

 

·       Han B, Mehra R, Dhanasekaran SM, Yu J, Menon A, Lonigro RJ, Wang XS, Gong Y, Wang L, Shankar S, Laxman B, Shah RB, Varambally S, Palanisamy N, Tomlins SA, Kumar-Sinha C, Chinnaiyan AM.
A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: identification of DDX5-ETV4 fusion protein in prostate cancer. 
Cancer Research. 2008 68:7629-37

 

·       Wang XS*, Zhang Z*, Wang HC, Cai JL, Xu QW, Li MQ, Chen YC, Qian XP, Lu TJ, Yu LZ, Zhang Y, Xin DQ, Na YQ, Chen WF. 
Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. 
Clinical Cancer Research. 2006 12:4851-8

 

·       Wang XS*, Zhao H*, Xu Q, Jin W, Liu C, Zhang H, Huang Z, Zhang X, Zhang Y, Xin D, Simpson AJ, Old LJ, Na Y, Zhao Y, Chen W. 
HPtaa database-potential target genes for clinical diagnosis and immunotherapy of human carcinoma. 
Nucleic Acids Research. 2006 34:D607-12

 

·       Du P, Yu LZ, Ma M, Geng L, Wang XS, Xin DQ, Na YQ.
Expression of SSX2 gene in human urologic neoplasms.
Chinese journal of surgery. 2005 15;43(6):379-81

 

·       Wang XS, Ge CL, Guo RX, Guo KJ, He SG. 
Clinical classification and timing of surgery for gallstone acute pancreatitis. 
Chinese Journal of General Surgery. 2002 11:131-134

 

·       Wang XS, Zhang DX, Wang Y, Su D, Ge C, Guo R, Ito H. 
Gallstone acute pancreatitis: diagnosis and treatment. 
Journal of abdominal emergency medicine. 2002 22:491-498 (Japanese).

 

Wang Laboratory @ University of Pittsburgh Cancer Institute.